SBH Sciences

A provider of in vitro cell-based assays and services, SBH has especially good resources for startups in oncology and inflammation, with over 300 human cancer cell lines and over 30 cytokine expressing cell lines stocked in-house.  Other platforms include protein production, ELISA, Luminex and PCR.  Visit the SBH website here:  sbhsciences.com

CNBE-INRS

Based in Laval, Quebec, CNBE-INRS is an academic-affiliated CRO specializing in in vivo safety pharmacology, plus some efficacy models in autoimmune, metabolic and infectious diseases.  A large range of animal species are maintained in-house, including rodents, dogs, pigs, ferrets, monkeys and a range of farm animals.  Visit the CNBE website at cnbe.inrs.ca/en/contract-research.

Cell Assays
IC50
Drug Screening
Radiation Screening
3D Spheroid Cultures
Kinase Assays
Protein Production

Please contact us at info@nepn.net to discus your drug program needs.

Flank xenografts
Orthotopic tumor models
NASH fibrosis model
Autoimmune models
Arthritis model
HSV
Infectious

PK / ADME

In Vitro

NEPN  Northeast Preclinical Network

Xtal

Xtal provides high resolution structural data about drug leads, protein docking sites and antibody-antigen binding structures.  Other biophysical tests available for ligand-target interactions.  Learn more about crystallography services here: xtalbiostructures.com

NEPN CRO Services: The Northeast Preclinical Network is comprised of multiple contract research organizations (CROs) in the northeast of North America, each a specialist in a service vital to the preclinical development of biopharmaceutical drugs.   ​Together, NEPN CRO members offer entrepreneurs and drug program managers an integrated experience of service, from discovery to IND.  All members share mutual confidentiality agreements and can refer or subcontract pieces of work, as customers prefer. Please contact us for NEPN preclinical services.

Creagen

A chemistry-based, drug discovery CRO located in Woburn, MA, offering medicinal chemistry and synthesis services in addition to incubator space.  Creagen also has collections of novel natural product and natural product-like scaffolds for drug discovery.   Learn more here: creagenbio.com

Medicinal Chemistry
SAR
Batch Synthesis
NMR
Preformulation
Nanoformulation

Nepn Preclinical Services

​ELISA
Luminex
Flow/FACS
Western blot
PBMCs
Q-PCR​

​HPLC, LC-MS
​LC-HRAM

Bioanalysis

In Vivo Efficacy

Therapeutic Areas:

NovaBioAssays

A one stop shop for quantitative and qualitative bioanalysis of large and small molecules using LC/MS and LC-fluorescence based platforms.  Offering a full suite of bioanalytical services for proteins, antibody-drug conjugates (ADC), oligonucleotides, lipids and small molecules based pharmaceutical and biomarker programs.. Learn more here : novabioassays.com

Northeast Preclinical Network 

Specialist CRO Members

  • Oncology, Cancer
  • Autoimmune
  • Inflammation
  • Vaccine & Infectious
  • Metabolic Diseases​
X-ray Crystallography
Ligand binding kinetics
Epigenetics
Bromodomains
MOA studies
​Enzymology

Pharmacokinetics, DMPK
PK/PD - small and large animals
MTD
ADME
Acute & chronic toxicity
Histology
IHC

Target ID

Chemistry

Woodland Biosciences

Based in Boston metrowest, Woodland Biosciences offers mouse and rat-base in vivo efficacy services, mostly in cancer and NASH.  We specialize in lethal, solid cancers such as liver, colon, pancreas, lung and brain, and also offer some models for breast and heme cancers.  Woodland offers PI-led personalized attention to your drug program.  Visit the Woodland Biosciences website at woodlandbiosciences.com